Product Name :TBCD polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Tubulin-specific chaperone D: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane . Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis . Involved in neuron morphogenesis
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of TBCD protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :KIAA0988; SSD1; TFCD; Tubulin-specific chaperone D; Beta-tubulin cofactor D; tfcD; SSD-1; Tubulin-folding cofactor D
Immunogen :A synthetic peptide encompassing a sequence within the center region of human TBCD.
Modification :Unmodification
