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DPPA3 polyclonal antibody

货号: BS32331

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS32331

Product Name :DPPA3 polyclonal antibody

Host :Rabbit

Reactivity :Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Developmental pluripotency-associated protein 3: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. M...

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of DPPA3 protein.

BiowMW :~17.7 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :STELLAR; Developmental pluripotency-associated protein 3; Stella-related protein

Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human DPPA3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of PLC gamma 1 expression in Jurkat (A) whole cell lysates.

免疫沉淀（IP）