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DHCR7 polyclonal antibody

货号: BS31191

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS31191

Product Name :DHCR7 polyclonal antibody

Swiss-Prot :Q9UBM7

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/2000)

Background :7-dehydrocholesterol reductase: Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core . Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (By similarity). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation

Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :The antibody was purified by immunogen affinity chromatography.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of DHCR7 protein

BiowMW :~54.5 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :D7SR; 7-dehydrocholesterol reductase; 7-DHC reductase; Putative sterol reductase SR-2; Sterol Delta(7)-reductase

Immunogen :Recombinant fusion protein of human DHCR7.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of HSD3B1 expression in human placenta (A) whole cell lysates.

免疫沉淀（IP）