Product Name :CD16.2 monoclonal antibody
Background :Low affinity immunoglobulin gamma Fc region receptor III-A: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) . Binds with intermediate affinity to both IgG2a and IgG2b . Can bind to IgG2a and IgG2b monomers . Does not display binding to IgG1 or IgG3 . Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection . On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses . Mediates neutrophil activation by IgG complexes redundantly with FCGR2A . Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a . Also acts as a receptor for the Fc region of immunoglo...
Product :Armenian Hamster IgG. 1mg/ml in PBS, pH 7.3, and 0.02% sodium azide.
Purification&Purity :The antibody was purified by affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes mouse CD16.2
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Low affinity immunoglobulin gamma Fc region receptor IV; CD16-2; FcgammaRIV
Immunogen :FCγR4 —EC domain fusion with IgG1 Fc
Modification :Unmodification
