产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

SMAD1 monoclonal antibody

货号: MB23463

价格：￥ 1200

货期：现货（1-2个工作日）

25ug 50ug 100ug 200ug

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB23463

Product Name :SMAD1 monoclonal antibody

Swiss-Prot :Q15797

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB:1/500 - 1/2000

Background :The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :52.3kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1

Immunogen :Purified recombinant fragment of human SMAD1 (AA: 1-110) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using SMAD1 mouse mAb against Hela (1), HepG2 (2), MCF-7 (3), C2C12 (4), A431 (5), A549 (6), LNCap (7), NIH/3T3 (8) and PC-12 (9) cell lysate.