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PDHA1 monoclonal antibody

货号: MB23430

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB23430

Product Name :PDHA1 monoclonal antibody

Swiss-Prot :P08559

Host :Mouse

Reactivity :Human

Applications :WB,FCM

Application_all :WB:1/500 - 1/2000 FC:1/200 - 1/400

Background :The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2b

BiowMW :43.3kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PDHA; PDHAD; PHE1A; PDHCE1A

Immunogen :Purified recombinant fragment of human PDHA1 (AA: 241-390) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using PDHA1 mouse mAb against HepG2 (1), HL-60 (2),SK-OV-3 (3),PC-3 (4) and PANC-1 (5) cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）