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BCL6 monoclonal antibody

货号: MB23305

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB23305

Product Name :BCL6 monoclonal antibody

Swiss-Prot :P41182

Host :Mouse

Reactivity :Human

Applications :WB,IHC,IF,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :78.8KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BCL5; LAZ3; BCL6A; ZNF51; ZBTB27

Immunogen :Purified recombinant fragment of human BCL6 (AA: 507-706) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using BCL6 mouse mAb against Jurkat (1), K562 (2), Raji (3), Ramos (4) and MOLT-4 (5) cell lysate.

Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using BCL6 mouse mAb with DAB staining.

Immunofluorescence analysis of Hela cells using BCL6 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of HL-60 cells using BCL6 mouse mAb (green) and negative control (red).