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NUP98 monoclonal antibody

货号: MB23122

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB23122

Product Name :NUP98 monoclonal antibody

Swiss-Prot :P52948

Host :Mouse

Reactivity :Human, Monkey

Applications :WB,IF,FCM

Application_all :WB:1/500 - 1/2000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin.</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :197.5kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ADIR2; NUP96; NUP196; Nup98-96

Immunogen :Purified recombinant fragment of human NUP98 (AA: 1-218) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using NUP98 mouse mAb against A549 (1), L-02 (2), Hela (3), Jurkat (4), HL-60 (5), COS7 (6), HT-29 (7), and A431 (8) cell lysate.