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CD40 monoclonal antibody

货号: MB23033

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB23033

Product Name :CD40 monoclonal antibody

Swiss-Prot :P25942

Host :Mouse

Reactivity :Human

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200-1/1000 FC:1/200-1/400

Background :This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :30.6kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :p50; Bp50; CDW40; TNFRSF5

Immunogen :Purified recombinant fragment of human CD40 (AA: extra(21-193)) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CD40 mouse mAb against Raji cell lysate.

Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD40 mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）