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CCND1 monoclonal antibody

货号: MB23017

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB23017

Product Name :CCND1 monoclonal antibody

Swiss-Prot :P24385

Host :Mouse

Reactivity :Human, Mouse

Applications :WB,FCM

Application_all :WB:1/500 - 1/2000 FC:1/200-1/400

Background :The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers.</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :33.7kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BCL1; PRAD1; U21B31; D11S287E

Immunogen :Purified recombinant fragment of human CCND1 (AA: 1-295) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CCND1 mouse mAb against LNCAP (1), and NIH/3T3 (2) cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）