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CTNNB1 monoclonal antibody

货号: MB23003

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB23003

Product Name :CTNNB1 monoclonal antibody

Swiss-Prot :P35222

Host :Mouse

Reactivity :Human, Mouse, Rat, Monkey

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200-1/1000 FC:1/200-1/400

Background :The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :85.5kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CTNNB; MRD19; armadillo;Beta-catenin

Immunogen :Purified recombinant fragment of human CTNNB1 (AA: 632-781) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CTNNB1 mouse mAb against Hela (1), HepG2 (2),NIH3T3 (3),MCF-7 (4), C6 (5),COS-7 (6),K562 (7),Jurkat (8), A549 (9),SH-SY5Y (10),BEL-7402 (11), HEK293 (12), and HEK293-6e (13) cell lysate.

Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CTNNB1 mouse mAb with DAB staining.