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MSH2 monoclonal antibody

货号: MB22848

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB22848

Product Name :MSH2 monoclonal antibody

Swiss-Prot :P43246

Host :Mouse

Reactivity :Human, Mouse

Applications :WB,IHC,IF,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :104.7kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FCC1; COCA1; HNPCC; LCFS2; hMSH2; HNPCC1

Immunogen :Purified recombinant fragment of human MSH2 (AA: 442-586) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using MSH2 mouse mAb against Hela (1), NIH/3T3 (2), A549 (3), and A431 (4) cell lysate.

Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using MSH2 mouse mAb with DAB staining.

Immunofluorescence analysis of Hela cells using MSH2 mouse mAb. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Flow cytometric analysis of Hela cells using MSH2 mouse mAb (green) and negative control (red).