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ELANE monoclonal antibody

货号: MB22443

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB22443

Product Name :ELANE monoclonal antibody

Swiss-Prot :P08246

Host :Mouse

Reactivity :Human,Monkey

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 FC:1/200 - 1/400

Background :Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.<br />

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :28.5kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GE; NE; HLE; HNE; ELA2; SCN1; PMN-E

Immunogen :Purified recombinant fragment of human ELANE (AA: 140-267) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using ELANE mouse mAb against U937 (1), SPC-A-1 (2), and COS7 (3) cell lysate.

Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using ELANE mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）