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CBX5 monoclonal antibody

货号: MB22084

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB22084

Product Name :CBX5 monoclonal antibody

Swiss-Prot :P45973

Host :Mouse

Reactivity :Human,Mouse

Applications :WB,IHC,IF

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000

Background :This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. <br />

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :22.2kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :HP1; HP1A; HEL25

Immunogen :Purified recombinant fragment of human CBX5 (AA: 1-191) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CBX5 mouse mAb against Hela (1), NIH/3T3 (2), K562 (3), MCF-7 (4), and A431 (5) cell lysate.

Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using CBX5 mouse mAb with DAB staining.

Immunofluorescence analysis of Hela cells using CBX5 mouse mAb. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.