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SHC1 monoclonal antibody

货号: MB21862

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21862

Product Name :SHC1 monoclonal antibody

Swiss-Prot :P29353

Host :Mouse

Reactivity :Human,Mouse

Applications :WB,IF,FCM

Application_all :WB:1/500 - 1/2000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :62.8kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SHC; SHCA

Immunogen :Purified recombinant fragment of human SHC1 (AA: 385-495) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using SHC1 mouse mAb against NIH/3T3 cell lysate.

Immunofluorescence analysis of A431 cells using SHC1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)