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CASP8 monoclonal antibody

货号: MB21532

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB21532

Product Name :CASP8 monoclonal antibody

Swiss-Prot :Q14790

Host :Mouse

Reactivity :Human,Mouse,Monkey,Rat

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 FC:1/200 - 1/400

Background :This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :26kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473

Immunogen :Purified recombinant fragment of human CASP8 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CASP8 mouse mAb against Hela (1), Jurkat (2), THP-1 (3), NIH/3T3 (4), Cos7 (5) and PC-12 (6) cell lysate.

Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using CASP8 mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）