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C-CBL monoclonal antibody

货号: MB21507

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21507

Product Name :C-CBL monoclonal antibody

Swiss-Prot :P22681

Host :Mouse

Reactivity :Human,Mouse,Rat,Monkey,Rabbit

Applications :WB,IHC,IF,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/100 - 1/500 IF:1/50 - 1/500 FC:1/200 - 1/400

Background :The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :120kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CBL; CBL2; NSLL; C-CBL; RNF55

Immunogen :Purified recombinant fragment of human C-CBL expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using C-CBL mouse mAb against RAJI (1), RAW264.7 (2), K562 (3), SKBR-3 (4), 3T3-L1 (5), THP-1 (6) and PC-12 (7) cell lysate.

Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using C-CBL mouse mAb with DAB staining.

Immunofluorescence analysis of Hela cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Flow cytometric analysis of MCF-7 cells using C-CBL mouse mAb (blue) and negative control (red).