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PINCH monoclonal antibody

货号: MB21500

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21500

Product Name :PINCH monoclonal antibody

Swiss-Prot :P48059

Host :Mouse

Reactivity :Human

Applications :WB,IF,FCM

Application_all :IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Product :Ascitic fluid containing 0.03% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :37kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PINCH; PINCH1; PINCH-1; LIMS1

Immunogen :Purified recombinant fragment of human PINCH expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using PINCH mouse mAb against A549 (1), Jurkat (2), and Hela (3) cell lysate.

Immunofluorescence analysis of HepG2 cells using PINCH mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.