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ApoE monoclonal antibody

货号: MB21474

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21474

Product Name :ApoE monoclonal antibody

Swiss-Prot :P02649

Host :Mouse

Reactivity :Human

Applications :IHC,FCM

Application_all :IHC:1/200 - 1/1000 FC:1/200 - 1/400

Background :Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :36kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AD2; LPG; LDLCQ5; MGC1571

Immunogen :Purified recombinant fragment of human ApoE expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemical analysis of paraffin-embedded human liver cancer tissues (left) and brain tissues (right) using ApoE mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）