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FOXD3 monoclonal antibody

货号: MB21397

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21397

Product Name :FOXD3 monoclonal antibody

Swiss-Prot :Q9UJU5

Host :Mouse

Reactivity :Human,Mouse,Monkey

Applications :WB

Application_all :WB:1/500 - 1/2000

Background :FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells .Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :48kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AIS1; HFH2; Genesis; FOXD3

Immunogen :Purified recombinant fragment of human FOXD3 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using FOXD3 mouse mAb against NTERA-1 (1)?HUVE-12 (2), HEK293 (3), Hela (4), Jurkat (5), NIH/3T3 (6), K562 (7), RAW264.7 (8) and COS7 (9) cell lysate.