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STAT3 monoclonal antibody

货号: MB21391

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21391

Product Name :STAT3 monoclonal antibody

Swiss-Prot :P40763

Host :Mouse

Reactivity :Human,Mouse,Rat,Monkey

Applications :WB,IHC,IF

Application_all :WB:1/500-1/1000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000

Background :The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :88kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :APRF; HIES; FLJ20882; MGC16063; STAT3

Immunogen :Purified recombinant fragment of human STAT3 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using STAT3 mouse mAb against Hela (1),NIH/3T3 (2), Jurkat (3), PC-12 (4) and COS7 (5) cell lysate.

Immunohistochemical analysis of paraffin-embedded human mammary cancer tissues (left) and lung cancer tissues (right) using STAT3 mouse mAb with DAB staining.

Immunofluorescence analysis of Hela cells using STAT3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.