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FAK monoclonal antibody

货号: MB21286

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21286

Product Name :FAK monoclonal antibody

Swiss-Prot :Q05397

Host :Mouse

Reactivity :Human,Mouse

Applications :WB,IHC,IF

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000

Background :This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This cellular localization is directed by a

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :119kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FAK; FADK; FAK1; FRNK; pp125FAK; PTK2

Immunogen :Purified recombinant fragment of human FAK expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using FAK mouse mAb against A549 (1) and NIH/3T3 (2) cell lysate.

Immunohistochemical analysis of paraffin-embedded human cervices tumour using FAK mouse mAb with DAB staining

Immunofluorescence analysis of B16 cells using FAK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.

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