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PGA5 monoclonal antibody

货号: MB21262

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB21262

Product Name :PGA5 monoclonal antibody

Swiss-Prot :P0DJD9

Host :Mouse

Reactivity :Human

Applications :WB,IHC

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000

Background :PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.

Product :Ascitic fluid containing 0.03% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :42kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Pepsinogen 5; Pepsin A

Immunogen :Purified recombinant fragment of human PGA5 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using PGA5 mouse mAb against HepG2 (1) and SMMC-7721 (2) cell lysate.

Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using PGA5 mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）