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DAXX monoclonal antibody

货号: MB21257

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21257

Product Name :DAXX monoclonal antibody

Swiss-Prot :Q9UER7

Host :Mouse

Reactivity :Human

Applications :WB,IF,FCM

Application_all :WB:1/500 - 1/2000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :81kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DAP6; EAP1; BING2

Immunogen :Purified recombinant fragment of human DAXX expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using DAXX mouse mAb against K562 cell lysate (1).

Confocal Immunofluorescence analysis of PANC-1 cells using DAXX mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.

免疫沉淀（IP）

免疫组织化学（IHC）