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GATA4 monoclonal antibody

货号: MB21241

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21241

Product Name :GATA4 monoclonal antibody

Swiss-Prot :P43694

Host :Mouse

Reactivity :Human,Rat

Applications :WB

Application_all :WB:1/500 - 1/2000

Background :GATA binding protein 4, also known as GATA4, it is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.

Product :Ascitic fluid containing 0.03% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2b

BiowMW :46kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MGC126629

Immunogen :Purified recombinant fragment of human GATA4 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using GATA4 mouse mAb against rat fetal heart (1) and adult heart (2) tissues lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）