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FMR1 monoclonal antibody

货号: MB21209

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21209

Product Name :FMR1 monoclonal antibody

Swiss-Prot :Q06787

Host :Mouse

Reactivity :Human

Applications :WB,IHC,IF

Application_all :IHC:1/200 - 1/1000 IF:1/200 - 1/1000

Background :FMR1, also known as POF, FMRP, FRAXA. Entrez Protein: NP_002015. It is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :71kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :POF; FMRP; POF1; FRAXA

Immunogen :Purified recombinant fragment of human FMR1 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using FMR1 mouse mAb against Jurkat (1) and K562 (2) cell lysate.

Immunohistochemical analysis of paraffin-embedded human brain tissues, showing cytoplasmic localization with DAB staining using FMR1 mouse mAb.

Immunofluorescence analysis of NIH/3T3 cells using FMR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.