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MAPK10 monoclonal antibody

货号: MB21155

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB21155

Product Name :MAPK10 monoclonal antibody

Swiss-Prot :P53779

Host :Mouse

Reactivity :Human,Mouse

Applications :WB,IF

Application_all :WB:1/500 - 1/2000 IF:1/200 - 1/1000

Background :MAPK10: mitogen-activated protein kinase 10, also known as JNK3, JNK3A, PRKM10, p54bSAPK. Entrez Protein NP_002744. It is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Product :Ascitic fluid containing 0.03% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :53kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :JNK3; JNK3A; PRKM10; p54bSAPK

Immunogen :Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using MAPK10 mouse mAb against NIH/3T3 (1) and SKN-SH (2) cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）