Product Name :OAS1 polyclonal antibody
Applications :WB, IHC, IF/ICC
Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200
Background :The 2'-, 5'- oligoadenylate synthetases (OASs) are interferon-induced proteins that play a putative role in mediating resistance to virus infection, control of cell growth, differentiation and apoptosis. OAS1, which functions as a homotetramer, is characterized by its capacity to catalyze the synthesis of 2'-, 5'- oligomers of adenosine (2-5As). OAS1 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, activating latent RNase L which, when activated, cleaves single-stranded RNAs. This RNase L activity leads to the inhibition of cellular protein synthesis and the impairment of viral replication. OAS1, a 400 amino acid containing protein, is also important in evaluating the interferon response in RNAi studies, and is implicated in diabetes mellitus susceptibility.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :OAS1 polyclonal antibody detects endogenous levels of OAS1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :(2 5')oligo(A) synthetase 1;
(2-5'')oligo(A) synthase 1;
2 5 Oligoadenylate Synthetase 1;
2 5' oligo A synthase 1;
2 5' oligo A synthetase 1;
2 5A synthase 1;
2 5A synthetase 1;
2' 5' oligo A synthetase 1;
2' 5' oligoadenylate synthetase 1 40/46kDa;
2' 5' oligoadenylate synthetase 1;
2' 5' oligoisoadenylate synthetase 1;
2''-5''-oligoadenylate synthase 1;
2'5' oligo A synthetase 1;
2'5' oligoadenylate synthetase 1;
2'5' oligoisoadenylate synthetase 1;
2-5A synthase 1;
E18/E16;
IFI 4;
IFI4;
OAS 1;
OAS1;
OAS1_HUMAN;
OIAS;
OIASI;
p46/p42 OAS;
Immunogen :Recombinant full length protein of human OAS1.
Modification :Unmodification
