Product Name :AMICA1 polyclonal antibody
Application_all :WB,1:500 - 1:1000
Background :Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :AMICA1 polyclonal antibody detects endogenous levels of AMICA1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :JAML;AMICA;AMICA1;CREA7-1;CREA7-4;Gm638
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human AMICA1.
Modification :Unmodification
