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KMT2A polyclonal antibody

货号: BS74827

价格：

一口价 ：￥ 800

货期：现货（1-2个工作日）

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No. :BS74827

Product Name :KMT2A polyclonal antibody

Swiss-Prot :Q03164

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB

Application_all :WB,1:500 - 1:2000

Background :This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :KMT2A polyclonal antibody detects endogenous levels of KMT2A protein.

BiowMW :180kDa

Note :For research use only, not for use in diagnostic procedure.

促销价格1 :460

促销价格2 :800

Alternative Name :KMT2A;ALL-1;CXXC7;HRX;HTRX1;MLL;MLL1;MLL1A;TRX1;WDSTS;MLL-AF9;MLL/GAS7;TET1-MLL

Immunogen :Recombinant full length protein of human KMT2A.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of KMT2A expression in SHSY5Y (A), Hela (B), Jurkat (C), mouse lung (D) whole cell lysates.