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AHA1 polyclonal antibody

货号: BS71870

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS71870

Product Name :AHA1 polyclonal antibody

Swiss-Prot :O95433

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:100|IF/ICC,1:50 - 1:200

Background :AHA-1 stimulates the inherent ATPase activity of yeast and human HSP 90 and interacts with the cytoplasmic tail of vesticular stomatitis virus glycoprotein. AHA-1 regulates HSP 90 by influencing the conformational state of the “ATP lid” and consequent N-terminal dimerization. It is crucial for cell viability under non-optimal growth conditions when HSP 90 levels are limiting. AHA-1 is a cytosolic protein and may transiently interact with the endoplasmic reticulum. It can have an affect on one step in the endoplasmic to Golgi trafficking. AHA-1 is expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, in liver and placenta. It is induced by heat shock and treatment with the HSP 90 inhibitor 17-demeth-oxygeldanamycin.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AHA1 polyclonal Antibody detects endogenous levels of AHA1 protein.

BiowMW :~ 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C14orf3; Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human AHA1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of AHA1 expression in HEK293T (A), Hela (B), U2OS (C) whole cell lysates.

Immunohistochemical analysis of AHA1 staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of AHA1 staining in A549 cells.

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