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HDAC6 polyclonal antibody

货号: BS6784

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6784

Product Name :HDAC6 polyclonal antibody

Swiss-Prot :Q9UBN7

Host :Rabbit

Reactivity :Human, Mouse, Rat, Rabbit

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:100 - 1:500

Background :Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :HDAC6 polyclonal antibody detects endogenous levels of HDAC6 protein.

BiowMW :131KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0901; Histone deacetylase 6; HD6

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human HDAC6.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of HDAC6 expression in HCT116 (A), K562 (B), MCF7 (C), BV2 (D), C6 (E) whole cell lysates.

Immunohistochemical analysis of HDAC6 staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of HDAC6 staining in HeLa cells.

Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection

JournalClinical And Experimental Pharmacology And Physiology

ApplicationWB,IF

IF2.336

SpeciesMouse

PMID22651689
HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway

JournalNeurobiology Of Aging

ApplicationWB,IF

IF4.398

SpeciesMouse

PMID26507311