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LKB1 polyclonal antibody

货号: BS6740

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6740

Product Name :LKB1 polyclonal antibody

Swiss-Prot :Q15831

Host :Rabbit

Reactivity :Human, Mouse, Rat,Monkey

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:100 - 1:500

Background :This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :LKB1 polyclonal antibody detects endogenous levels of LKB1 protein.

BiowMW :48kDa/60kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human LKB1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of LKB1 expression in HEK293 (A), rat heart (B) whole cell lysates.

Immunohistochemical analysis of LKB1 staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of LKB1 staining in A431 cells.

Fluoxetine suppresses AMP-activated protein kinase signaling pathway to promote hepatic lipid accumulation in primary mouse hepatocytes

JournalInternational Journal Of Biochemistry & Cell Biology

ApplicationWB,IF

IF3.144

SpeciesMouse

PMID
Decreased Expression of LKB1 Correlates with Poor Prognosis in Hepatocellular Carcinoma Patients Undergoing Hepatectomy

JournalAsian Pacific Journal of Cancer Prevention

ApplicationIHC

IF0

SpeciesHuman

PMID23679304