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Bcl-XL polyclonal antibody

货号: BS6453

价格：

一口价 ：￥ 800

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6453

Product Name :Bcl-XL polyclonal antibody

Swiss-Prot :Q07817

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:100 - 1:500

Background :The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bcl-XL polyclonal antibody detects endogenous levels of Bcl-XL protein.

BiowMW :30KDa

Note :For research use only, not for use in diagnostic procedure.

促销价格1 :460

促销价格2 :800

Alternative Name :BCL2L1;BCL-XL/S;BCL2L;BCLX;Bcl-X;PPP1R52;BCL2 like 1;Bcl-XL

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Bcl-XL.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Bcl-XL expression in Jurkat (A), HeLa (B) whole cell lysates.

Immunohistochemical analysis of Bcl-XL staining in human colon cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of Bcl-XL staining in Jurkat cells.

Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease

JournalCell Death & Disease

ApplicationWB

IF5.959

SpeciesRat

PMID26203862
Proteolysis targeting peptide (PROTAP) strategy for protein ubiquitination and degradation

JournalBiochemical And Biophysical Research Communications

ApplicationWB

IF3.575

SpeciesHuman

PMID26826379