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IL6 polyclonal antibody

货号: BS62100

价格：

一口价 ：￥ 800

货期：现货（1-2个工作日）

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No. :BS62100

Product Name :IL6 polyclonal antibody

Swiss-Prot :P05231

Host :Rabbit

Reactivity :Human, Mouse, Rat, Monkey

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :Acute phase response is induced by interleukin-6 (IL-6) produced by T cells, macrophages, fibroblasts, endothelial and other cells . IL-6 induces proliferation or differentiation in many cell types including B cells, thymocytes and T cells. IL-6, in concert with TGF-β, is important for developing Th17 responses. IL-6 binds to IL-6Rα and through this association induces gp130 homodimerization . gp130 homodimerization triggers the Jak/Stat cascade and the SHP-2/Erk MAP kinase cascade . IL-6 also forms a complex with an IL-6Rα splice variant that is nonmembrane-associated . The IL-6/soluble IL-6Rα complex can then activate the gp130 signaling pathway in cells that express gp130 but not IL-6Rα . Research studies have shown that IL-6, through increasing expression of proangiogenic VEGF, may also contribute to metastatic breast cancer.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL6 polyclonal antibody detects endogenous levels of IL6 protein.

BiowMW :28;18kDa

Note :For research use only, not for use in diagnostic procedure.

促销价格1 :460

促销价格2 :800

Alternative Name :Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2; IL6; IFNB2

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of IL6 expression in Hela (A), U87MG (B), HuT78 (C), A549 (D), MCF7 (E) whole cell lysates.

Immunohistochemical analysis of IL6 staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of IL6 staining in KYSE40 cells.

Western blot analysis of IL6 expression in U87MG (A), mouse brain (B), mouse kidney (C), rat kidney (D) whole cell lysates.

Silencing aquaporin 1 inhibits autophagy to exert anti-rheumatoid arthritis effects in TNF-α-induced fibroblast-like synoviocytes and adjuvant-induced arthritis rats

JournalINFLAMMATION RESEARCH

ApplicationWB

IF4.8

SpeciesRat

PMID39774992