Product Name :DCC Recombinant Rabbit mAb
Reactivity :Human, Mouse, Rat
Applications :WB,IHC-P,FC,IP
Application_all :WB: 1:1000; IHC-P: 1:500-1:2000; FC: 1:20-1:50; IP: 1:20-1:50
Background :This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :The antibody detects endogenous levels of it
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1
Immunogen :Recombinant protein of human DCC
Modification :Unmodification
