Product Name :Apolipoprotein H Recombinant Rabbit mAb
Applications :WB,IHC-P,ICC/IF,FC,IP
Application_all :WB: 1:1000; IHC-P: 1:200-1:500; ICC/IF: 1:100; FC: 1:200-1:500; IP: 1:20-1:50
Background :Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]
Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :The antibody detects endogenous levels of it
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :BG; B2G1; B2GP1; APOH; Beta-2-glycoprotein 1
Immunogen :Recombinant protein of human Apolipoprotein H
Modification :Unmodification
