Product Name :Phospho-Pyrin (Ser241) Recombinant Rabbit mAb
Application_all :WB: 1:1000
Background :Predicted to enable actin binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in positive regulation of inflammatory response and positive regulation of interleukin-1 beta production. Predicted to be located in nucleus. Predicted to be part of canonical inflammasome complex and microtubule associated complex. Predicted to be active in cytosol and nucleoplasm. Is expressed in bladder; central nervous system; female associated reproductive structure; ureter; and urethra of female. Used to study familial Mediterranean fever. Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to human MEFV (MEFV innate immunity regulator, pyrin). [provided by Alliance of Genome Resources, Apr 2025]
Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :The antibody detects endogenous levels of it
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :FMF; pyrin; TRIM20
Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser241 of mouse Pyrin
Modification :Phosphorylated
