Product Name :TRPV4 Recombinant Rabbit mAb
Application_all :IHC-P: 1:200-1:500
Background :Enables several functions, including SH2 domain binding activity; calcium channel activity; and osmosensor activity. Involved in several processes, including cellular response to osmotic stress; positive regulation of MAPK cascade; and positive regulation of cytokine production. Acts upstream of or within hyperosmotic salinity response; regulation of response to osmotic stress; and vasopressin secretion. Located in adherens junction and cilium. Is active in plasma membrane. Is expressed in several structures, including brain; limb; respiratory system; sensory organ; and skeleton. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2025]
Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :The antibody detects endogenous levels of it
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Trp12; VRL-2; VROAC; OTRPC4; VR-OAC; 0610033B08Rik
Immunogen :A synthetic peptide of mouse TRPV4
Modification :Unmodification
