Product Name :CNOT7 Recombinant Rabbit mAb
Reactivity :Human,Mouse,Rat
Applications :WB,ICC/IF,FC,IP
Application_all :WB: 1:1000 ; ICC/IF: 1:500-1:1000 ; FC: 1:200-1:1000 ; IP: 1:20-1:50
Background :Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation.
Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :The antibody detects endogenous levels of it
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Caf1; Pop2; CAF-1; AU022737
Immunogen :A synthetic peptide of mouse CNOT7
Modification :Unmodification
