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RPA70 Recombinant Rabbit mAb

货号: BS47144

价格：

一口价 ：￥ 880

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS47144

Product Name :RPA70 Recombinant Rabbit mAb

Swiss-Prot :P27694

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:2000-1:20000

Background :This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]

Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :The antibody detects endogenous levels of it

BiowMW :70 kDa

Note :For research use only, not for use in diagnostic procedure.

促销价格1 :508

促销价格2 :880

促销价格3 :1580

Alternative Name :HSSB; RF-A; RP-A; REPA1; RPA70; MST075

Immunogen :A synthetic peptide of human RPA70

Conjugate :Unconjugated