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Chk2 Recombinant Rabbit mAb

货号: BS46882

价格：

一口价 ：￥ 880

货期：现货（1-2个工作日）

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No. :BS46882

Product Name :Chk2 Recombinant Rabbit mAb

Swiss-Prot :O96017

Host :Rabbit

Reactivity :Human

Applications :WB,IHC,ICC/IF,FC,IP

Application_all :WB: 1:5000-1:10000 ; IHC: 1:20-1:100 ; ICC/IF: 1:50 ; FC: 1:20 ; IP: 1:20-1:50

Background :In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :The antibody detects endogenous levels of it

BiowMW :61 kDa

Note :For research use only, not for use in diagnostic procedure.

促销价格1 :508

促销价格2 :880

促销价格3 :1580

Alternative Name :CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425

Immunogen :Recombinant protein of human Chk2

Conjugate :Unconjugated