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Presenilin 2 Recombinant Rabbit mAb

货号: BS45263

价格：

一口价 ：￥ 880

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS45263

Product Name :Presenilin 2 Recombinant Rabbit mAb

Swiss-Prot :P49810

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-P,ICC/IF,FC,IP

Application_all :WB: 1:2000-1:20000 ; IHC-P: 1:200-1:500 ; ICC/IF: 1:50-1:200 ; FC: 1:20-1:50 ; IP: 1:20

Background :Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :The antibody detects endogenous levels of it

BiowMW :23 kDa

Note :For research use only, not for use in diagnostic procedure.

促销价格1 :508

促销价格2 :880

促销价格3 :1580

Alternative Name :AD4; PS2; AD3L; STM2; CMD1V

Immunogen :A synthetic peptide of human Presenilin 2

Conjugate :Unconjugated