Product Name :Phospho-MLKL (Ser345) Recombinant Rabbit mAb
Applications :WB,ICC/IF,IP
Application_all :WB: 1:1000 ; ICC/IF: 1:100-1:200 ; IP: 1:100-1:200
Background :This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Product :1mg/ml in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :The antibody detects endogenous levels of it
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :9130019I15Rik
Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser345 of mouse MLKL
Modification :Phosphorylated
