Product Name :Recombinant RSK1 Rabbit mAb
Reactivity :Human, Mouse, Rat
Applications :WB, IHC, IF/ICC, IP
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200), IP (1/10 - 1/50)
Background :Ribosomal protein S6 kinase alpha-1: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (By similarity). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (By similarity). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (By similarity). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosp...
Product :1mg/ml in PBS, pH 7.3, 50% glycerol, 0.05% BSA, and 0.05% Proclin300.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of RSK1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1
Immunogen :A synthetic peptide encompassing a sequence within human RSK1 protein.
Modification :Unmodification
