Product Name :MAdCAM-1 Rat mAb
Application_all :IF/ICC (1/50 - 1/200), FC (1/500 - 1/2000)
Background :Mucosal addressin cell adhesion molecule 1: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding
Product :Rat IgG2a kappa . 1mg/ml in PBS, pH 7.3, and 0.02% sodium azide.
Purification&Purity :The antibody was purified by affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes mouse MAdCAM-1
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1
Immunogen :Endothelial cells
Modification :Unmodification
