Product Name :CD278 Rat mAb
Application_all :IF/ICC (1/50 - 1/200), FC (1/500 - 1/2000)
Background :Inducible T-cell costimulator: Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response . Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells . Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection . Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling . In addition, activates PI3K signaling pathways independently of calcium flux . Essential both for efficient interaction between T and B-cells and for nor...
Product :Rat IgG2b kappa. 1mg/ml in PBS, pH 7.3, and 0.02% sodium azide.
Purification&Purity :The antibody was purified by affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes mouse CD278
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :AILIM; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278
Immunogen :Mouse ICOS cDNA and ICOS hexahistidine fusion protein
Modification :Unmodification
