Product Name :SLCO2A1 polyclonal antibody
Reactivity :Human, Mouse, Rat
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :Solute carrier organic anion transporter family member 2A1: Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane . PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever . Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination . PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions . Uses lactate, generated by glycolysis, as a counter-substrate to mediate PGE2 influx and efflux . Under nonglycolytic conditions, metabolites other than lactate might serve a...
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of SLCO2A1 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :OATP2A1; SLC21A2; Solute carrier organic anion transporter family member 2A1; Prostaglandin transporter; PGT; Solute carrier family 21 member 2
Immunogen :A synthetic peptide encompassing a sequence within the center region of human SLCO2A1.
Modification :Unmodification
