Product Name :FBXO16 polyclonal antibody
Application_all :WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Background :F-box only protein 16: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Functions as a putative tumor suppressor by targeting nuclear beta-catenin/CTNNB1 for degradation independently of upstream activating signals, thereby inhibiting epithelial-to-mesenchymal transition . Controls the ubiquitination and degradation of hnRNPL . Negatively regulates NF-kappa-B signaling by mediating the polyubiquitination and degradation of RELA . Inhibits autophagy by promoting 'Lys-48'-linked polyubiquitination of the serine/threonine-protein kinase ULK1
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of FBXO16 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :FBX16; F-box only protein 16
Immunogen :A synthetic peptide encompassing a sequence within the C-terminal region of human FBXO16.
Modification :Unmodification
