Product Name :ZSWIM7 polyclonal antibody
Application_all :WB (1/500 - 1/1000)
Background :Zinc finger SWIM domain-containing protein 7: Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR) . Forms a heterodimeric complex with ZSWIM7/SWS1 that promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA . The SWSAP1-ZSWIM7/SWS1 heterodimer is essential during meiosis by stabilizing DMC1 filaments . In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) . IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid
Product :1mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :The antibody was purified by immunogen affinity chromatography.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of ZSWIM7 protein
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :SWS1; Zinc finger SWIM domain-containing protein 7; SWIM domain-containing and Srs2-interacting protein 1 homolog; SWIM-type zinc finger domain-containing protein 7
Immunogen :A synthetic peptide encompassing a sequence within the center region of human ZSWIM7.
Modification :Unmodification
